Heritability of Inhibitory Gating of the P50 Auditory-Evoked Potential in Monozygotic and Dizygotic Twins
作者:
David A. Young,
Merilyne Waldo,
James H. Rutledge, III,
Robert Freedman,
期刊:
Neuropsychobiology
(Karger Available online 1996)
卷期:
Volume 33,
issue 3
页码: 113-117
ISSN:0302-282X
年代: 1996
DOI:10.1159/000119260
出版商: S. Karger AG
关键词: Heritability;Auditory-evoked potential;Twins;monozygotic and dizygotic;Likelihood profile
数据来源: Karger
摘要:
Most normal subjects suppress the P50 evoked response to repeated auditory stimulus when paired stimuli are presented, 500 ms apart. The ratio of the amplitude of the response to the second stimulus to that of the first forms a quantitative measure of the activity of a central inhibitory sensory gating mechanism. The variance of this measure in a group of monozygotic and dizygotic twin pairs was determined. The calculation of heritability (h2) indicates that a significant portion of the variance (0.44 or greater) is due to heritable factors. This study supports the use of the inhibitory gating of the P50 response as a phenotype for genetic studies of schizophrenia in which a P50 gating abnormality has been identified.
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