首页   按字顺浏览 期刊浏览 卷期浏览 Cell Cycle Position Affects Response of Normal Fibroblasts to Phorbol Esters
Cell Cycle Position Affects Response of Normal Fibroblasts to Phorbol Esters

 

作者: M.Ralph,  

 

期刊: Growth Factors  (Taylor Available online 1988)
卷期: Volume 1, issue 1  

页码: 85-90

 

ISSN:0897-7194

 

年代: 1988

 

DOI:10.3109/08977198809000250

 

出版商: Taylor&Francis

 

关键词: cell cycle;mitotic delay;fibroblast;EGF

 

数据来源: Taylor

 

摘要:

AbstractTumor-promoting phorbol ester derivatives are known to stimulate as well as inhibit the cell cycle traverse of many kinds of cells, but it is not known whether or how these effects are related to tumor promotion. It is shown here that the potency of the phorbol diester PMA (phorbol myristate acetate) to cause a delay of cell division depends on the cell cycle position at the beginning of exposure to the PMA. Quiescent human fibroblasts were stimulated with epidermal growth factor, and PMA was added to the cultures at different times after stimulation. The later PMA was added, the stronger was the mitotic delay it caused. This means that cells which become exposed while they are in an early stage of the cycle are less effectively delayed and reach mitosis earlier than those for which exposure begins at a later stage of the cycle. The data indicate that PMA is actually able to reverse the order in which the cells of a normally growing population divide. In organized tissues this could disturb the intercellular communication which may be linked to the relative cell cycle positions of neighboring cells.

 

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