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Nonparametric Estimation of Specific Occurrence/Exposure Rate in Risk and Survival Analysis

 

作者: GuttiJogesh Babu,   C.Radhakrishna Rao,   M.Bhaskara Rao,  

 

期刊: Journal of the American Statistical Association  (Taylor Available online 1992)
卷期: Volume 87, issue 417  

页码: 84-89

 

ISSN:0162-1459

 

年代: 1992

 

DOI:10.1080/01621459.1992.10475178

 

出版商: Taylor & Francis Group

 

关键词: Berry-Esseen bound;Bootstrap;Competing risks;Kaplan-Meier estimate;Mixed censoring;Strong approximation

 

数据来源: Taylor

 

摘要:

A cohort of individuals exposed to some risk is followed up to a point of timeM, and observations on two random variables (Y, Δ) are recorded for each individual. The variable Δ refers to one of the four possible events that can occur for an individual in the period [0,M]: (i) dies of a specific disease, say cancer, (ii) dies of a natural cause, (iii) withdraws from the study, and (iv) is alive and still under study at timeM. The variableYrefers to the time at which an event occurs. Based on such data fornindividuals, we consider the problem of estimation of a specific occurrence/exposure rate (SOER), which is a risk ratio defined as the ratio of probability of death due to cancer in the interval [0,M]to the mean lifetime of all individuals up to the time pointM. The asymptotic distribution of a nonparametric estimator of SOER is shown to be normal, and the asymptotic variance involves unknown parameters. Various ways of bootstrapping are discussed for construction of confidence intervals for SOER and compared. Some numerical illustrations are provided.

 

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