Modulation of the neurotransmitter release in rat cerebellar neurons by GROβ
作者:
Davide Ragozzino,
Aldo Giovannelli,
Anna Mileo,
Cristina Limatola,
Angela Santoni,
Fabrizio Eusebi,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 16
页码: 3601-3606
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Cerebellar excitatory post synaptic currents;Cerebellar granules;Cerebellar slices;Chemokines;Extra-cellular signal-regulated kinases
数据来源: OVID
摘要:
WE report here that, in cultured cerebellar granule cells, the CXC chemokine GRO β stimulates the signaling pathway of the extracellular signal-regulated kinases, and enhances both evoked and spontaneous post-synaptic currents in patch clamped Purkinje neurons from rat cerebellar slices. The GRO β-induced enhancement of the excitatory post-synaptic currents evoked by stimulating the parallel fibres is blocked by the inhibitor of the extracellular signal-regulated kinases pathway PD98059, which also reduces both basal frequency of spontaneous post-synaptic currents and mean amplitude of evoked excitatory post-synaptic currents. Our results suggest that GRO β modulates neurotransmitter release in the cerebellum through the activation of the extra-cellular signal-regulated kinases pathway.
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