Experimental therapy of systemic lupus erythematosus: the treatment of NZB/W mice with mouse soluble interferon‐γ receptor inhibits the onset of glomerulonephritis
作者:
Laurence Ozmen,
Danièle Roman,
Michael Fountoulakis,
Georges Schmid,
Bernhard Ryffel,
Gianni Garotta,
期刊:
European Journal of Immunology
(WILEY Available online 1995)
卷期:
Volume 25,
issue 1
页码: 6-12
ISSN:0014-2980
年代: 1995
DOI:10.1002/eji.1830250103
出版商: WILEY‐VCH Verlag GmbH
关键词: Soluble interferon‐γ receptor;Glomerulonephritis;NZB/W mice
数据来源: WILEY
摘要:
AbstractFemale NZB/W F1 mice develop an autoimmune disease similar to human systemic lupus erythematosus (SLE), and ultimately die of glomerulonephritis. Starting at the age of 16 weeks NZB/W F1 mice were treated for a period of 19 weeks with soluble interferon‐γ receptor (sIFN‐γR), anti‐IFN‐γ monoclonal antibody (mAb) or IFN‐γ. All mice treated with sIFN‐γR or anti‐IFN‐γ mAb were alive 4 weeks after the treatment was discontinued, whereas 50% of mice died in the placebo groups and 78% of the mice died in the IFN‐γ‐treated group. Histologically, there was severe membrano‐proliferative glomerulonephritis in IFN‐γ‐ and placebo‐treated mice, and minimal or no mesangioproliferative disease in mice receiving sIFN‐γR or anti‐IFN‐γ mAb. The renal mononuclear infiltrate (T lymphocytes and monocytes), expression of major histocompatibility complex class II antigen and glomerular immunoglobulin and complement deposition were reduced in those mice. These data suggest that an IFN‐γ inhibitor, such as the soluble IFN‐γR, can be used f
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