A simple and rapid densitometric method has been developed for simultaneous determination of betamethasone valerate and miconazole nitrate in cream preparations. After extraction of the analyte with 96 % ethanol, the extracts were spotted on pre–coated silica gel plates, which were eluted two times with a mixture of chloroform–acetone–glacial acetic acid, 34+4+3 (v/v/v). Quantitative evaluation was performed by measuring the absorbance reflectance of the analyte spots at λ = 233 nm. The densitometric method is selective, precise, and accurate, and can be used for routine analysis of the cream preparations in pharmaceutical industry quality control laboratories.