Spectrofluorimetric Determination of Chlorpromazine Hydrochloride and Thioridazine Hydrochloride
作者:
FardosA. Mohamed,
期刊:
Analytical Letters
(Taylor Available online 1995)
卷期:
Volume 28,
issue 14
页码: 2491-2501
ISSN:0003-2719
年代: 1995
DOI:10.1080/00032719508004030
出版商: Taylor & Francis Group
关键词: Spectrofluorimetry;phenothiazines;chlorpromazine HCl;thioridazine HCl;N. bromosuccinimide phenothiazines' determination;pharm. analysis
数据来源: Taylor
摘要:
Fluorescence spectroscopy was applied to the development of a sensitive and simple method for the determination of chlorpromazine HCl and thioridazine-HCl. The method is based upon development of an intense fluorescence using N-bromosuccinimide as the fluorogenic reagent. The produced fluorescence has very characteristic excitation and emission spectra and was stable for at least one hour. The results were reproducible and as little as 5 ng/ml chloropromazine HCl and 1 ng/ml thioridazine-HCl could be determined. The method was applied successfully to the analysis of various commercially available dosage forms. The obtained results were in good agreement with those of the official BP 93 procedures.
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