Rapid Correction of Metabolic Acidosis in Chronic Renal Failure: Effect on Parathyroid Hormone Activity
作者:
Kuo-Cheng Lu,
Shang-Der Shieh,
Bi-Lian Li,
Pauling Chu,
Shun-Yin Jan,
Yuh-Feng Lin,
期刊:
Nephron
(Karger Available online 1994)
卷期:
Volume 67,
issue 4
页码: 419-424
ISSN:1660-8151
年代: 1994
DOI:10.1159/000188015
出版商: S. Karger AG
关键词: Chronic renal failure;Secondary hyperparathyroidism;Metabolic acidosis;Free calcium clamp
数据来源: Karger
摘要:
To investigate the effect of rapid correction of chronic metabolic acidosis on circulating intact parathyroid hormone (I-PTH) activity by free calcium clamp in chronic renal failure, 18 patients were enrolled in this study. Metabolic acidosis was corrected by continuous bicarbonate infusion while plasma ionized calcium was clamped at the preinfusion level throughout the entire procedure. The plasma pH, bicarbonate, total CO2, sodium, serum total calcium and 1,25(OH)2 vitamin D3 levels increased significantly while serum concentrations of I-PTH, alkaline phosphatase and albumin showed significant decreases after bicarbonate infusion. The plasma ionized calcium, potassium, serum magnesium and inorganic phosphorus levels showed no significant difference before and after bicarbonate infusion. These results demonstrate that rapid correction of metabolic acidosis attenuates circulating PTH activity in chronic renal failure and may underline the importance of maintaining normal acid-base homeostasis particularly in the presence of secondary hyperparathyroidism.
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