The central complex (CC) is a prominent component of the adult insect brain. InDrosophila melanogaster, mutations which alter CC structure also impair adult locomotion. This has led to the suggestion that the CC functions as a higher organizer of adult locomotor patterns (Strauss and Heisenberg, 1993). In the present study, we describe altered larval behavior resulting from mutations in sixCCstructural genes. Differences from the control strain were found for larvae from eachCCmutant strain in at least one of three assays,central body defect1(cbd1), central complex deranged1(ccd1), central brain deranged1(ceb1)andcentral complex1(cex1)larvae all had general defects in locomotion (on a non-nutritive agar surface). Bothellipsoid body open2(ebo2)andno bridge1(nob1)had larval foraging behavior defects (on a nutritive yeast surface). Onlycex1larvae required significantly longer time in a roll over assay of muscle tone. Genetic analysis suggested thatnob1interacts additively with two other genes influencing larval foraging behavior,foraging (for)andChaser (Csr).foralso had an influence on adult foraging, whereas here we found thatCsrdid not. We did not include adult foraging behavior tests of the CC mutants due to general locomotion defects in these flies (Strauss and Heisenberg, 1993).