SummaryDigitalic compounds along with Na-poor diet, constitute the main basis of any maintenance therapy in heart failure. The choice of the compound for such a treatment should be dictated by safety and convenience. Due to their regular intestinal absorption and slow excretion, Digitoxin, acetylgitoxin and gitalin are especially indicated for long term therapy.Dosage should be adjusted to each patient : usually, it is 0.1 mg daily for digitoxin, 0.15 mg for acetyldigitoxin and 0.3–0.5 mg for gitalin.Gastro-intestinal or cardiac disturbances arc encountered rarely and with identical frequency for each of the three componds.Each drug has the same toxicity and potency. The choice is thus mainly determined by the physician’s habits.