The Indiana University Cyclotron Facility (IUCF) is in the process of designing and building the Midwest Proton Radiation Institute (MPRI) [1]. The design process includes the development of several patient treatment systems. This paper discusses the use of two such systems that provide for the high precision positioning of a patient. They are the Patient Positioner System and the X‐ray system. The Patient Positioner System positions an immobilized patient on a support device to a treatment position based on a prescribed Treatment Plan. The X‐ray system uses an industrial robot arm to position a Digital Radiography Panel to acquire an X‐ray image to verify the location of the prescribed treatment volume in a patient by comparing the acquired images with reference images obtained from the patient’s Treatment plan. © 2003 American Institute of Physics