Likelihood-Based Models for Genetic Linkage Analysis Using Affected Sib Pairs
作者:
Jane M. Olson,
期刊:
Human Heredity
(Karger Available online 1997)
卷期:
Volume 47,
issue 2
页码: 110-120
ISSN:0001-5652
年代: 1997
DOI:10.1159/000154398
出版商: S. Karger AG
关键词: Identity by descent;Gene mapping;Two-locus models;Multipoint;Variance components
数据来源: Karger
摘要:
Risch [Am J Hum Genet 1990;46:229-253] recently developed a likelihood method for testing genetic linkage using affected sib pairs. This paper proposes a reparameterization of the Risch likelihood in terms of genetic variance components divided by the affected-sib-pair ascertainment probability. The new parameters allow for ease of interpretation, particularly for multilocus models. A single-degree-of-freedom test of the total disease genetic effect at a marker locus can be constructed that has power comparable to the likelihood ratio ‘triangle’ test. Extension of the models to other types of relative pairs is also discussed. The models may be used in genome scanning and in studying single or multilocus models of inherita
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