Electrochemical Behavior and Determination of Nicardipine
作者:
Joseph Wang,
BalasahebK. Deshmukh,
Mojtaba Bonakdar,
期刊:
Analytical Letters
(Taylor Available online 1985)
卷期:
Volume 18,
issue 9
页码: 1087-1102
ISSN:0003-2719
年代: 1985
DOI:10.1080/00032718508069102
出版商: Taylor & Francis Group
关键词: nicardipine;voltammetry;flow injection;adsorptive accumulation
数据来源: Taylor
摘要:
The voltammetric behavior and measurement of nicardipine at the glassy carbon, carbon paste and hanging mercury drop electrodes are discussed. Cyclic voltammetry is used to elucidate the redox mechanism. Nicardipine is shown to adsorb on carbon electrodes, with the surface species retaining its electroactive characteristics. The adsorptive accumulation serves as a preconcentration step which improves the voltammetric measurement with respect to selectivity and sensitivity. Coupling this with a medium-exchange step eliminates interferences due to solution-phase electroactive species and permits direct measurement in urine. The inherent sensitivity of differential pulse voltammetry at the mercury electrode permits convenient measurement at the submicromolar level, with detection limit of 2 × 10−8M. Amperometric detection for a flow injection system is illustrated.
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