The problem of sequencing mixed model assembly lines is characterized by a set of parameters whose values are dictated by the actual manufacturing environment. In some cases, it may be desirable to minimize the size of the facility, while in others, the throughput time is paramount. Important design considerations include operator schedules, the product mix, station boundaries, and the launching discipline. The intent of this paper is to present a common mathematical framework in which each possible variant can be addressed. By implication, a solution technique developed for one can be readily adopted for the others.