Intravenous Ampicillin Pharmacokinetics in the Third Trimester of Pregnancy
作者:
Renee Kubacka,
Harold Johnstone,
Henry Tan,
Peter Reeme,
Steven Myre,
期刊:
Therapeutic Drug Monitoring
(OVID Available online 1983)
卷期:
Volume 5,
issue 1
页码: 55-60
ISSN:0163-4356
年代: 1983
出版商: OVID
关键词: Ampicillin;Pharmacokinetics;Pregnancy
数据来源: OVID
摘要:
SummaryThe pharmacokinetics of a single dose of intravenous ampicillin were studied in nine patients during their third trimester of pregnancy. Each volunteer was given either 500 mg (5.7–8.8 mg/kg) or 1 g (15.4–21.4 mg/kg) of sodium ampicillin by rapid infusion. Postinfusion plasma concentration—time curves followed biexponential decay in all subjects. Calculated parameters included a mean plasma distribution volume of 177.1 ± 97.5 ml/kg, tissue or peripheral distribution volume of 246.2 ± 143.9 ml/kg, elimination half-life of 1.60 ± 0.51 h, and total body clearance of 4.59 ± 1.48 ml/min/kg. Dose-dependent disposition was not observed. Gestation-specific drug therapy research during pregnancy is discussed.
点击下载:
PDF
(437KB)
返 回