Nonspecific Immunostimulation with Low Doses of Cyclophosphamide (LDCY), Thymostimulin, and Echinacea Purpurea Extracts (Echinacin) in Patients with Far Advanced Colorectal Cancers: Preliminary Results
作者:
LerschChristian,
ZeunerMartin,
BauerAndrea,
SiemensMichaela,
HartRainer,
DrescherMichael,
FinkUlrich,
DancygierHenryk,
ClassenMeinhard,
期刊:
Cancer Investigation
(Taylor Available online 1992)
卷期:
Volume 10,
issue 5
页码: 343-348
ISSN:0735-7907
年代: 1992
DOI:10.3109/07357909209024793
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Outpatients (n = 15) with metastasizing far advanced colorectal cancers received immunotherapy consisting of low-dose cyclophosphamide (LDCY) 300 mg/m2every 28 days i.v., thymostimulin 30 mg/m2, days 3-10 after low-dose cyclophosphamide i.m. once daily, then twice a week, and echinacin 60 mg/m2together with thymostimulin i.m. All patients had had previous surgery and/or chemotherapy and had progressive disease upon entering the study. Two months after onset of therapy a partial tumor regression was documented in one and a stable disease in 6 other patients by abdominal ultrasonography, decrease of the tumor markers carcinoem-bryonic antigen (CEA), CA 19-9, CA 15-3, and/or chest roentgenography, which may also be attributed to the natural course of disease. Mean survival time was 4 months, 2 patients survived for more than 8 months. Immunotherapy was well tolerated by all patients without side effects.
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