Circadian Variations of Neurotransmitter Binding in Three Age Groups of Rats
作者:
Susanne Jenni-Eiermann,
H.P. von Hahn,
C.G. Honegger,
期刊:
Gerontology
(Karger Available online 1985)
卷期:
Volume 31,
issue 3
页码: 138-149
ISSN:0304-324X
年代: 1985
DOI:10.1159/000212695
出版商: S. Karger AG
关键词: Rat brain;Receptor binding;Circadian cycle;Neurotransmitters;Phase shifts
数据来源: Karger
摘要:
Binding in 14 ligand membrane receptor pairs and choline acetyltransferase activity were studied at 4-hour intervals during a 24-hour cycle (12:12 light:dark). Cortex, hippocampus, cerebellum, striatum and brainstem were prepared from 3-, 12- and 24-month-old male rats. Cholinergic, α- and β-adrenergic, dopaminergic, serotonergic, gabaergic and opiate binding were determined. In the aged animals, the times of the binding maxima are no longer locked to the same time of the light:dark cycle, and the cycle phases themselves are shifted in comparison to those of the young and adult group. Cycle amplitudes were smallest in the 12-month-old rats, increasing significantly in the 24-month group. The age changes in the overall (24-hour) means fall into 4 different patterns, none of which shows a linear age-related decrease. This points out the great importance of including an adult group (12 months) in all ageing studies on small mammal
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