Efficacy of Prophylactic Antibiotics for CraniotomyA Meta‐analysis
作者:
Fred Barker,
期刊:
Neurosurgery
(OVID Available online 1994)
卷期:
Volume 35,
issue 3
页码: 484-492
ISSN:0148-396X
年代: 1994
出版商: OVID
关键词: Antibiotic prophylaxis;Craniotomy;Meta-analysis;Surgical wound infection
数据来源: OVID
摘要:
A META-ANALYSIS OF published randomized studies comparing prophylactic antibiotics to placebo in craniotomies was performed. Ten studies were examined; eight met criteria for inclusion into the meta-analysis. The analysis showed an advantage of antibiotics over placebo at theP< 10−8level. Tests for homogeneity of effect size between the individual studies showed similar effects of antibiotic treatment between trials, despite variation in the randomization methods and antibiotic regimens used. No statistically significant difference was detected between antibiotic regimens that did or did not cover gram-negative organisms or between single- and multiple-dose regimens. Cumulative meta-analyses showed that this conclusion could have been confidently drawn by 1988, after only four of the eight eligible trials had been published. Trials published since that time have reinforced these conclusions but have not significantly altered them. Future studies should compare proposed new antibiotic regimens with one of those already demonstrated to be effective, not with a placebo.
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