A Disease Resembling Junctional Epidermolysis Bullosa in a Toy Poodle
作者:
Robert Dunstan,
Robert Sills,
J. Wilkinson,
Amy Paller,
Ken Hashimoto,
期刊:
The American Journal of Dermatopathology
(OVID Available online 1988)
卷期:
Volume 10,
issue 5
页码: 442-447
ISSN:0193-1091
年代: 1988
出版商: OVID
关键词: Animal Model;Junctional epidermolysis bullosa;Mechanobullous disease.
数据来源: OVID
摘要:
A disease resembling junctional epidermolysis bullosa in humans is described in a toy poodle. Shortly after birth, the affected animal developed vesicles and bullae on the pads of the feet and the mucous membranes of the oral cavity. The lesions rapidly increased in number and severity, eventually involving the glabrous skin of the ventral abdomen. Due to the severity of the lesions, the animal was euthanized when it was 48 h old. Histopathologic, ultrastructural and immunohistochemical evaluation defined a minimally inflamed subepidermal vesicular disease with separation occuring at the zona lucida of the basement membrane zone. Laminin and type IV collagen were present at the base of the vesicle.
点击下载:
PDF
(442KB)
返 回