Chemotherapy-induced Acral Erythema: Desquamating Lesions Involving the Hands and Feet
作者:
Stephen Kroll,
Charles Koller,
Susan Kaled,
Samuel Dreizen,
期刊:
Annals of Plastic Surgery
(OVID Available online 1989)
卷期:
Volume 23,
issue 3
页码: 263-265
ISSN:0148-7043
年代: 1989
出版商: OVID
数据来源: OVID
摘要:
Patients receiving very high doses of chemotherapeutic drugs, particularly cytarabine (cytosine arabinoside, ara-C, Cytosar), may develop chemotherapy-induced acral erythema, a painful toxic rash of the palmar surfaces of the hands that progresses to edema, blister formation, and desquamation. In more severe cases, the feet are involved, and they show similar changes. Plastic surgeons may be consulted because of the hand involvement and the clinical resemblance, after desquamation, to a very superficial second-degree burn. In patients who have had bone marrow transplantation, this diagnosis must be distinguished from graft-versus-host reaction—a desquamating skin lesion that can affect a similar anatomical area but that is progressive and productive of serious consequences. Acral erythema appears to be self-limited and requires only supportive treatment.
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