Time‐dependent reversal of dentate LTP by 5 Hz stimulation
作者:
Stephen Martin,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 17
页码: 3775-3781
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Depotentiation;Hippocampus;Long-term potentiation (LTP);Low frequency stimulation
数据来源: OVID
摘要:
FIELD potential recordings were made from the dentate gyrus of urethane-anaesthetized rats in order to investigate the ability of 5 Hz stimulation to reverse long-term potentiation (LTP) induced by a high frequency tetanus. A 10 min train of 5 Hz was found to reverse LTP in a time-dependent fashion: as the interval between tetanus and 5 Hz was increased, LTP became progressively less susceptible to reversal. If 10 min or 30 min intervened between tetanization and 5 Hz stimulation, LTP was unaffected. These results indicate that dentate LTPin vivoexhibits a similar limited time window of vulnerability to reversal by low frequency stimulation to that previously reported in area CA 1in vitro.
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