Developmental Aspects of Renal β‐Amino Acid Transport. III. Ontogeny of Transport in Isolated Renal Tubule Segments
作者:
AARON FRIEDMAN,
DIANE JAX,
RUSSELL CHESNEY,
期刊:
Pediatric Research
(OVID Available online 1981)
卷期:
Volume 15,
issue 1
页码: 10-13
ISSN:0031-3998
年代: 1981
出版商: OVID
数据来源: OVID
摘要:
Isolated renal tubules were prepared from newborn and adult Sprague-Dawley rats. They were used to study the uptake and accumulation of the β-ammo acid, taurine, by renal epithelium. Initial rate as well as steady-state kinetics were studied. Initial rate studies revealed heterogeneity of uptake in newborn and adult tubules. Slower uptake was present in the newborn in the low-affinity system. Slowed efflux was found in neonatal tissue. Newborn tubules in contrast to adult tubules demonstrated uptake under anaerobic conditions. Adult and newborn tissues showed decreased uptake of taurine when incubated with β-alanine. Physiologic taurinuria, be it in the rat or man, may be due to less rapid initial uptake and/or slowed efflux from renal epithelium.
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