Coordinate Expression of Hypothalamic Pro-Dynorphin and Pro-Vasopressin mRNAs with Osmotic Stimulation
作者:
Thomas G. Sherman,
Olivier Civelli,
James Douglass,
Ed Herbert,
Stanley J. Watson,
期刊:
Neuroendocrinology
(Karger Available online 1986)
卷期:
Volume 44,
issue 2
页码: 222-228
ISSN:0028-3835
年代: 1986
DOI:10.1159/000124649
出版商: S. Karger AG
关键词: Pro-dynorphin mRNA;Pro-vasopressin mRNA;Coordinate expression;Salt-loading
数据来源: Karger
摘要:
Peptides derived from pro-dynorphin and pro-vasopressin precursors coexist within neurosecretory vesicles of magnocellular neurons in the rat hypothalamus projecting to the posterior pituitary. The secretory activity of these neurons can be stimulated using physiological manipulations known to increase plasma vasopressin levels, such as dehydration and salt-loading. With chronic osmotic challenge, the mRNAs for both pro-dynorphin and pro-vasopressin increase in parallel in the supraoptic and paraventricular nuclei of the hypothalamus, but not within the nonmagnocellular suprachiasmatic nucleus cell groups projecting elsewhere than the neural lobe. The results indicate an example of coordinate regulation of mRNA expression for coexisting peptides within the brain.
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