Long‐term immunogenicity and safety of an inactivated hepatitis A vaccine in haemophilic patients
作者:
PIETRO DENTICO,
NICOLA CIAVARELLA,
FRANCESCO A. SCARAGGI,
MARIO SCHIAVONI,
ANNA VOLPE,
ANTONIO FASANO,
ANTONIA PERRICCI,
ROSALBA BUONGIORNO,
期刊:
Haemophilia
(WILEY Available online 1996)
卷期:
Volume 2,
issue 1
页码: 37-40
ISSN:1351-8216
年代: 1996
DOI:10.1111/j.1365-2516.1996.tb00008.x
出版商: Blackwell Publishing Ltd
关键词: HAV;HAV vaccine;HIV;haemophiliacs;inactivated vaccine;vaccine
数据来源: WILEY
摘要:
Summary.As a consequence of recent outbreaks of HAV infection by blood products, 91 patients, haemophiliacs and subjects with bleeding disorders (10 of whom were also anti‐HIV positive) susceptible to HAV infection received a formalin‐inactivated hepatitis A vaccine (HAVRIX 720 Elisa Units, SmithKline Beecham). Subcutaneous injections were given in the deltoid region at 0, 1 and 6 months. The seroconversion rates and litres, expressed in GMT IU/1, were determined at 1, 2, 6, 7, 12, 18 and 24 months. No adverse reactions to the vaccine were observed. The highest percentage of responders observed was 98.7% in anti‐HIV negative and 71.4% in anti‐HIV positive patients. The anti‐HAV GMT titres were higher in anti‐HIV negative than in anti‐HIV positive patients. The inactivated hepatitis A vaccine is safe, clinically well tolerated, and provides long‐term protection agains
点击下载:
PDF
(317KB)
返 回