An Animal Model of Hepatotoxicity Associated with Halothane Anesthesia
作者:
I. Spies,
Burnell Brown,
期刊:
Anesthesiology
(OVID Available online 1976)
卷期:
Volume 45,
issue 6
页码: 622-628
ISSN:0003-3022
年代: 1976
出版商: OVID
关键词: Anesthetics, volatile;halothane: Toxicity;hepatic: Liver;hepatotoxicity: Biotransformation;enzyme induction: Pharmacology;Aroclor 1254
数据来源: OVID
摘要:
Hepatic necrosis was induced in rats by a single exposure to 1 per cent halothane in oxygen following pretreatment with a single dose of Aroclor 1254, a polychlorinated biphenyl. The hepatic lesion was centrilohular and multifocal, and morphologically similar to that reported to occur in man.In-vitroincubation with14C-halothaane indicated an enhanced covalent binding of halothane metabolites to hepatic microsomal macromolecules, particularly lipids, following Aroclor 1254 pretreatment. Lipoperoxidation of microsomal unsaturated fatty acids was not observed with these animals.
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