THE UW SOLUTION FOR CANINE KIDNEY PRESERVATIONITS SPECIFIC EFFECT ON RENAL HEMODYNAMICS AND MICROVASCULATURE
作者:
YUJI UEDA,
SATORU TODO,
OSCAR IMVENTARZA,
HIROYOKI FURUKAWA,
ALEJANDRA OKS,
YOU WU,
SHIRO OGUMA,
THOMAS STARZL,
期刊:
Transplantation
(OVID Available online 1989)
卷期:
Volume 48,
issue 6
页码: 913-917
ISSN:0041-1337
年代: 1989
出版商: OVID
数据来源: OVID
摘要:
The preservation effects of UW solution on renal hemodynamics and microvascular systems were studied in canine kidney autografts. In 72-hr UW-preserved kidneys, the microvessels of both cortex and medulla were completely visualized with silicon rubber compound 1 hr after reperfusion. Histology also showed extremely well-preserved arterioglomerular and tubular systems. These results were correlated with good renal blood flow, prompt recovery of posttransplant graft function, and 100% two-week survival of dogs. In contrast, kidneys preserved for 72 hr with Euro-Collins solution showed necrotic and obstructive changes of the microvasculature and deterioration of renal hemodynamics. In 120-hr UW-preserved kidneys, the microcirculation of the medullary region became poor after re-flow when there was fairly intact perfusion of the cortical region, indicating an ischemia-related intrarenal blood flow maldistribution. The 120-hr kidneys subsequently failed in spite of having a good blood flow and morphologically well-maintained microvasculature after reperfusion. These data demonstrated that much, but not all, of the beneficial effect of UW solution in kidney preservation might be attributed to its remark able protection of renal microvasculature. Correction of intrarenal blood maldistribution caused by a discrepancy in tolerance to ischemia of the vascular and tubular systems might be important in successfully preserving the kidney for 120 hr.
点击下载:
PDF
(698KB)
返 回