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Effect of ethosuximide on rest tremor in the MPTP monkey model

 

作者: Baltazar Gomez‐Mancilla,   Jean‐François Latulippe,   René Boucher,   Paul J. Bédard,  

 

期刊: Movement Disorders  （WILEY Available online 1992）
卷期: Volume 7, issue 2  

页码: 137-141

 

ISSN:0885-3185

 

年代: 1992

 

DOI:10.1002/mds.870070207

 

出版商: Wiley Subscription Services, Inc., A Wiley Company

 

关键词: Tremor;Monkey;MPTP;Ethosuximide

 

数据来源: WILEY

 

摘要:

AbstractBased on the hypothesis that low‐threshold calcium conductance in the thalamus might be involved in the pathophysiology of parkinsonian tremor, ethosuximide was given chronically to a monkey previously treated with MPTP and displaying exceptionally a typical rest tremor. After 5 days of daily treatment, the tremor was reduced by 60%. Diltiazem and verapamil which act on different calcium channels had no such effect. Ethosuximide also potentiated the antitremor effect of the dopamine D2agonist LY‐171

 

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