Topical Cyclosporin A in the Treatment of Anterior Segment Inflammatory Disease
作者:
Edward Holland,
Timothy Olsen,
Jeffrey Ketcham,
Craig Florine,
Jay Krachmer,
John Purcell,
Sheridan Lam,
Howard Tessler,
Joel Sugar,
期刊:
Cornea
(OVID Available online 1993)
卷期:
Volume 12,
issue 5
页码: 413-419
ISSN:0277-3740
年代: 1993
出版商: OVID
关键词: Cyclosporin A;Immunosuppression;Ocular inflammatory disease
数据来源: OVID
摘要:
Topical cyclosporin A was used in the management of 43 patients with a variety of anterior segment inflammatory disorders that had failed corticosteroid treatment. Treatment with topical cyclosporin A ranged from 1 week to 43 months, with a mean treatment period of 13 months. Thirty-five patients (81%) with disorders including highrisk keratoplasty, atopic and vernal keratoconjunctivitis, ligneous conjunctivitis, ulcerative keratitis, and Mooren's ulcer had a beneficial result, with resolution, reduction, or prevention of inflammation. Six patients (14%) with scleritis, ocular cicatricial pemphigoid, or endotheliitis showed no clinical improvement. Two patients (5%) had significant ocular discomfort, and the drug had to be discontinued in them. None of the other patients developed local side effects. Twenty-seven of these patients were followed with serial cyclosporin A blood levels and serum creatinine. None of these patients developed measurable drug blood levels or renal toxicity.
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