Quinolinic Aminoxyl Protects Albumin Against Peroxyl Radical Mediated Damage
作者:
TanfaniFabio,
CarloniPatricia,
DamianiElisabetta,
GreciLucedio,
WozniakMichal,
KulawiakDorota,
JankowskiKamil,
KaczorJacek,
MatuszkiewicsAndrzej,
期刊:
Free Radical Research
(Taylor Available online 1994)
卷期:
Volume 21,
issue 5
页码: 309-315
ISSN:1071-5762
年代: 1994
DOI:10.3109/10715769409056583
出版商: Taylor&Francis
关键词: Albumin;protein oxidation;quinolinic aminoxyl;antioxidants;free radicals
数据来源: Taylor
摘要:
A study of peroxyl radical-mediated bovine serum albumin oxidation in the presence of the quinolinic aminoxyl 1,2-dihydro-2,2-diphenyl-4-ethoxy-quinoline-1-oxyl (QAO) was carried out in order to test its efficiency as a protein antioxidant. Albumin oxidation was induced by thetert-butylhydroperoxide/PbO2system. The extent of protein oxidation, measured by monitoring the formation of carbonyl groups, was considerably reduced in the presence of QAO. ESR measurements were carried out to confirm the consumption of the nitroxide during oxidation and its incorporation in the protein. The data obtained indicate that the quinolinic aminoxyl function can be used as an effective antioxidant in biological systems.
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