Augmentation of Mitogen-Induced Interleukin 2 Production by Oral Administration of Polysaccharide SPR-901
作者:
TanakaMakoto,
MiyazakiHiroyuki,
TakedaYasuyuki,
TakeoSuguru,
YoshikaiYasunobu,
NomotoKikuo,
期刊:
Immunopharmacology and Immunotoxicology
(Taylor Available online 1992)
卷期:
Volume 14,
issue 3
页码: 403-420
ISSN:0892-3973
年代: 1992
DOI:10.3109/08923979209005401
出版商: Taylor&Francis
数据来源: Taylor
摘要:
AbstractThe effects of oral administration of antitumor polysaccharide SPR-901 (RBS), anα-1,3 branchedα-1,6 glucan, on concanavalin A (Con A)-induced interleukin 2 (IL-2) production of splenocytes were studied. The augmentation effect on Con A-induced IL-2 production was evident when more than 30 mg/kg of SPR-901 was administered orally to mice. On the other hand, oral administration of B512 dextran, an analogousα-1,6 glucan, did not show any augmentation effects on IL-2 production. The augmentation effect of SPR-901 on IL-2 production seemed to be mediated mainly by macrophages stimulated with SPR-901.
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