Gangliosides attenuate vincristine neurotoxicity on dorsal root ganglion cells
作者:
Kouji Houi,
Soichiro Mochio,
Takaaki Kobayashi,
期刊:
Muscle&Nerve
(WILEY Available online 1993)
卷期:
Volume 16,
issue 1
页码: 11-14
ISSN:0148-639X
年代: 1993
DOI:10.1002/mus.880160104
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: gangliosides;vincristine;neurotoxicity;microtubules;neuropathy
数据来源: WILEY
摘要:
AbstractWe investigated the effects of bovine brain gangliosides on the neurotoxicity of vincristine in dissociated cultures of dorsal root ganglion cells from 10‐day chick embryos. The effects of the drugs were quantified as the numbers of neurite‐bearing cells or total neurite length in individual neurite‐bearing cells. The administration of vincristine (1 to 1000 pg/mL) inhibited neurite outgrowth from the cells, whereas gangliosides (10 to 1000 m̈g/mL) protected them against this inhibition in a concentration‐dependent manner. Electron microscopy revealed vincristine‐induced fragmentation and longitudinal disorientation of microtubules in neurites and showed the protection by gangliosides against such damaging effects. Our results show that exogenous administration of gangliosides attenuates the neurotoxicity of vincristine in vitro. © 1993 John Wile
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