Drug‐Food Interaction Potential of Clarithromycin, A New Macrolide Antimicrobial
作者:
Sou‐yie Chu,
Y. Park,
Charles Locke,
David S. Wilson,
J. C. Cavanaugh,
期刊:
The Journal of Clinical Pharmacology
(WILEY Available online 1992)
卷期:
Volume 32,
issue 1
页码: 32-36
ISSN:0091-2700
年代: 1992
DOI:10.1002/j.1552-4604.1992.tb03784.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
To evaluate the effect of food on bioavailability, clarithromycin and 14‐hydroxy clarithromycin (active metabolite) pharmacokinetics were assessed in 26 healthy adult volunteers after ingestion of a single oral 500‐mg dose of clarithromycin in a fasting state (2 hours before breakfast after an overnight fast) and a nonfasting state (0.5 hours after the start of breakfast). Clarithromycin and 14‐hydroxy metabolite plasma concentrations were measured using a high‐performance liquid chromatographic technique. Food intake immediately before dosing increased the extent of absorption from the 500‐mg tablet formulation by approximately 25%. The mean increase in metabolite area under the plasma concentration‐time curve was approximately 9%. These results suggest that clarithromycin can be taken without regard to timing in relati
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