Insulin-Like Immunoreactivity in the Monkey Spinal Cord
作者:
S.S.W. Tay,
W.C. Wong,
期刊:
Cells Tissues Organs
(Karger Available online 1992)
卷期:
Volume 144,
issue 3
页码: 196-201
ISSN:1422-6405
年代: 1992
DOI:10.1159/000147307
出版商: S. Karger AG
关键词: Insulin;Immunoreactivity;Monkey;Spinal cord
数据来源: Karger
摘要:
Insulin-like immunoreactive neurons were localized in the cervical, thoracic, lumbar and sacral segments of the monkey spinal cord. Both dorsal and ventral horn cells were labelled. Insulin-like reaction product was localized in the cell nucleus and cytoplasm. Both inner and outer nuclear membranes were labelled. Reaction product appeared to be scattered throughout the nucleoplasm but not within the nucleolus. In the cytoplasm, labelling was mainly localized in the cisternae of rER and saccules of Golgi apparatus. Both proximal and distal dendrites were labelled, the reaction product was closely associated with the parallel arrays of neurotubules. Most of the distal dendrites were postsynaptic to non-labelled axon terminals; however, some were postsynaptic to lightly labelled axon terminals. A labelled dendrite often formed the central element of a synaptic glomerulus with several nonlabelled axon terminals. It is hypothesized that insulin-like substance(s) may be modulating nuclear activities as well as neuro-transmission at the synapse.
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