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Reduced Levels of Tissue Plasminogen Activator and Plasminogen Activator Inhibitor in Plasma of Patients with Familial Amyloidotic Polyneuropathy

 

作者: Bert-Ove Olofsson,   Torbjörn K. Nilsson,  

 

期刊: Pathophysiology of Haemostasis and Thrombosis  (Karger Available online 1990)
卷期: Volume 20, issue 1  

页码: 31-36

 

ISSN:1424-8832

 

年代: 1990

 

DOI:10.1159/000216102

 

出版商: S. Karger AG

 

关键词: Amyloidosis;Fibrinolysis;Plasminogen activator inhibitor;Tissue plasminogen activator

 

数据来源: Karger

 

摘要:

Tissue plasminogen activator (tPA) antigen levels and plasminogen activator inhibitor (PAI) activity were measured in the plasma from 23 patients with familial amyloidotic polyneuropathy. Both tPA levels and PAI activity were reduced to about half normal, even when the effects of patient age and body mass index were taken into account. There were higher mean tPA levels and PAI activity in patients with mild disability than in those with moderate or severe disability, but these differences were not statistically significant. There were normal tPA levels after venous occlusion of the upper arm, indicating a normal capacity of vascular endothelium to release tPA. This is the first reported disorder with reduced rather than increased basal tPA and PAI levels. The pathogenetic and clinical significances of these disturbances so far remain obscure.

 

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