Ditazole and Platelets
作者:
G. de Gaetano,
M.C. Tonolli,
M.P. Bertoni,
M.C. Roncaglioni,
期刊:
Pathophysiology of Haemostasis and Thrombosis
(Karger Available online 1977)
卷期:
Volume 6,
issue 2
页码: 127-136
ISSN:1424-8832
年代: 1977
DOI:10.1159/000214172
出版商: S. Karger AG
关键词: Platelet aggregation;Ditazole;Clot retraction;Thrombelastography;Gel-filtered platelets;Serotonin
数据来源: Karger
摘要:
Ditazole (4,5-diphenyl-2-bis-(2-hydroxyethyl)-aminoxazol) has been shown to be a strong in vitro inhibitor of human platelet aggregation brought about by release reaction inducers; in contrast, it did not significantly affect primary ADP-induced aggregation. Ditazole strongly inhibited the release of platelet-bound 14C-serotonin under the influence of Thrombofax, whereas it did not interfere with the transport and storage of serotonin in nonstimulated platelets. The effect of ditazole was not potentiated by acetyl-salicylic acid. Ditazole also inhibited ADP-reptilase clot retraction and modified thrombin-induced clot formation. The inhibition of platelet aggregation exerted by ditazole in plasma could be removed following gel filtration of platelets on Sepharose 2-B gel. This would indicate that ditazole does not act on platelets by a ‘hit and run’ mechan
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