Isolation and properties of cadmium‐binding protein induced in rat small intestine by oral administration of cadmium
作者:
Tetsuya Taguchi,
Kenichi Nakamura,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1982)
卷期:
Volume 9,
issue 3
页码: 401-409
ISSN:0098-4108
年代: 1982
DOI:10.1080/15287398209530173
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
The chromatographic properties and amino acid composition of Cd‐binding protein induced in the rat small intestine by oral administration of Cd were examined. When the intestinal mucosal cytosol from rats treated orally with Cd was chromatographed on Sephadex G‐75, Cd in the intestinal mucosa was bound 95.5% to protein of molecular weight about 10,000. A DEAE Sephadex A‐25 chromatogram of the Cd‐binding protein from Sephadex G‐75 showed two major and one minor Cd‐containing peaks as hepatic and renal metallothionein. The amino acid composition of the two major Cd peaks resembled that of metallothionein from other materials examined.
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