Immunoperoxidase Technique on Paraffin Sections Fails to Demonstrate Immunoglobulin Deposition in Cutaneous Lesions from Patients with Dermatomyositis
作者:
James Roebker,
Jeffrey Case,
Sheron Lear,
Steven Hodge,
Jeffrey Callen,
期刊:
The American Journal of Dermatopathology
(OVID Available online 1988)
卷期:
Volume 10,
issue 4
页码: 297-299
ISSN:0193-1091
年代: 1988
出版商: OVID
关键词: Dermatomyositis;Immunoperoxidase technique;Immunofluorescence technique
数据来源: OVID
摘要:
Nine formalin-fixed paraffin sections of skin biopsy specimens of patients with clinically and histologically proven dermatomyositis were studied using the avidin-biotin immunoperoxidase technique. No evidence of dermoepi-dermal junction or perivascular IgG, IgA, or IgM deposits were noted. These findings may be related to loss of antigenicity during the fixation process or to the small amount of immunoglobulin deposit previously reported in dermatomyositis. The negative findings demonstrate an inability to use this technique to find immmunoglobulin deposition retrospectively in dermatomyositis.
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