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Lymphomatoid Papulosis with Antigen Deletion and Clonal Rearrangement in a 4‐Year‐Old Boy

 

作者: Judith Hellman,   Robert G. Phelps,   Jim Baral,   Thomas M. Fasy,   Caitlin M. Ahern,   James A. Strauchen,  

 

期刊: Pediatric Dermatology  (WILEY Available online 1990)
卷期: Volume 7, issue 1  

页码: 42-47

 

ISSN:0736-8046

 

年代: 1990

 

DOI:10.1111/j.1525-1470.1990.tb01072.x

 

出版商: Blackwell Publishing Ltd

 

数据来源: WILEY

 

摘要:

AbstractLymphomatoid papulosis (LyP) is rarely seen in children. We report a case of LyP in a 4‐year‐old boy in whom immunopathologic studies demonstrated T cell antigen deletions. In contrast to all but two previous reports, a T suppressor (CD‐8) phenotype was predominant. Southern blot analysis of DNA isolated from a typical skin lesion indicated a clonal rearrangement of the T cell receptor β gene. Because of a 10% frequency of malignant lymphomas in patients with LyP, long‐term observation is cruciai, especially in chiidren. We recommend routine clonal rearrangement studies for aid in diagnosis and follow‐up, and as possible prognostic indicators in children with this

 

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