Transcranial Magnetic Stimulation: A Novel Antidepressive Strategy?
作者:
A. Conca,
St. Koppi,
P. König,
E. Swoboda,
N. Krecke,
期刊:
Neuropsychobiology
(Karger Available online 1996)
卷期:
Volume 34,
issue 4
页码: 204-207
ISSN:0302-282X
年代: 1996
DOI:10.1159/000119312
出版商: S. Karger AG
关键词: Transcranial magnetic stimulation;Electroconvulsive therapy;Major depression;Antidepressive medication;Add-on therapy
数据来源: Karger
摘要:
Transcranial magnetic stimulation (TMS) is a well-established diagnostic probe in neurological practice. The increasing knowledge of biological mechanisms in electroconvulsive therapy presents a clear case for studying the applicability of TMS as a therapeutic tool in psychiatry. Based on the results of our pilot study showing a possible antidepressive effect of TMS, we conducted a controlled clinical trial on patients affected by major depression (DSM-III-R). Group 1 (n = 12) underwent TMS as add-on therapy to standard antidepressive medication, while group 2 (n = 12) was treated only with antidepressive medication. Already after the third add-on TMS session, a statistically significantly greater remission of depressive symptoms occurred in the patients of group 1 (p = 0.003). This statistically significant difference between the groups became even more marked on the last day of the study (p = 0.001, Wilcoxon). The results and further implications of TMS in psychiatric disorders are discussed.
点击下载:
PDF
(778KB)
返 回