Differential Effects of GABAAand GABABReceptor Agonists on NMDA-Induced and Noradrenaline Induced Luteinizing-Hormone Release in the Ovariectomized Estrogen-Primed Rat
作者:
Tatsuo Akema,
Fukuko Kimura,
期刊:
Neuroendocrinology
(Karger Available online 1993)
卷期:
Volume 57,
issue 1
页码: 28-33
ISSN:0028-3835
年代: 1993
DOI:10.1159/000126338
出版商: S. Karger AG
关键词: γ-Aminobutyric Acid;GABAa Receptor;GABAb Receptor;Noradrenaline;N-Methyl-D-aspartate;Luteinizing hormone
数据来源: Karger
摘要:
Effects of selective γ-aminobutyric acida (GABAa) and GABAb receptor agonists on noradrenaline (NA)-induced and N-methyl-D-aspartate (NMDA)-induced luteinizing-hormone (LH) secretion were examined in ovariectomized estrogen-primed rats. Experiments were performed in unanesthetized animals bearing chronic intracerebroventricular (i.c.v.) cannulae. Lev. injections of NA or NMD A stimulated LH secretion in animals that had received prior i.c.v. injections of saline. The effects of NA and NMDA were significantly attenuated by a prior i.c.v. injection of phentolamine (a selective α-adrenergic-receptor blocker) and 2-amino-5-phosphonovaleric acid (a selective NMDA receptor antagonist), respectively. NA-induced LH release was also inhibited by i.c.v. injections of either muscimol (a selective GABAa receptor agonist) or baclofen (a selective GABAb receptor agonist). On the other hand, although muscimol inhibited the effect of NMDA, baclofen did not inhibit but slightly augmented the NMDA-induced release of LH. These results support the hypothesis that both GABAa and GABAb receptors are involved in the GABAergic inhibition of LH secretion, and further suggest that they are probably located at different sites in the neural mechanism regulating LH secretion in the female ra
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