Epithelial Cell Volume Regulation Illustrated by Experiments in Frog Skin
作者:
Hans H. Ussing,
期刊:
Kidney and Blood Pressure Research
(Karger Available online 1986)
卷期:
Volume 9,
issue 1-2
页码: 38-46
ISSN:1420-4096
年代: 1986
DOI:10.1159/000173074
出版商: S. Karger AG
关键词: Channels;Chloride;Cotransport;Epithelium;Frog skin;Gating;Potassium;Potential;Sodium;Volume
数据来源: Karger
摘要:
The volume control of the syncytium of principal cells (as opposed to the mitochondria-rich cells) is largely confined to the movement of ions and water through the basolateral membrane. The apical membrane is nearly tight to water and ions except sodium. The basolateral membrane is normally tight to chloride, but its chloride channels open if the cells swell osmotically or if the membrane is depolarized. If the epithelium has lost KC1 during osmotic swelling, it is recovered by a basolateral cotransport of KNaCl2
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