Effects of Ursodeoxycholic Acid on Hemodynamic and Renal Function Abnormalities Induced by Obstructive Jaundice in Rats
作者:
PooJorge L.,
EstanesAlma,
PedrazaJosé,
CruzCristino,
UribeMisael,
期刊:
Renal Failure
(Taylor Available online 1995)
卷期:
Volume 17,
issue 1
页码: 13-20
ISSN:0886-022X
年代: 1995
DOI:10.3109/08860229509036370
出版商: Taylor&Francis
关键词: Aldosterone;Cholestasis;Kidney;Liver function;Portal pressure;Renin;Ursodeoxycholic acid
数据来源: Taylor
摘要:
The mechanism of renal function abnormalities in experimental biliary cirrhosis can be partially explained by the absence of gastrointestinal bile flow, which predisposes to translocation of intestinal endotoxin, a potent renal vasoconstrictor. Since bile acids prevent the absorption of intestinal endotoxins, we aimed to evaluate the effects of ursodeoxycholic acid (UDCA) administration on renal function and hemodynamic abnormalities induced by 1 week of obstructive jaundice in rats. Methods: Fifty-two rats were used; 30 had ligation of the common bile duct, 22 were sham operated. Bile duct ligated rats were randomly and blindly assigned to receive UDCA (25 mg/kg/day, n = 14) or placebo (n = 16) during 1 week. Sham rats received no treatment. Portal pressure (PP) as well as creatinine clearance (CrCl), urinary sodium (US), and plasma renin activity (PRA) were evaluated. Results are mean±SEM, with a significant value of p<0.05. Results: Portal pressure (10.4±1.1 vs. 12.1±0.8 mm Hg) was significantly lower in UDCA than in placebo-treated rats. ALT serum levels were also significantly lower in bile duct ligated rats receiving UDCA (77.3±28 IU/L) than in placebo-treated rats (162±65 IU/L). US (1.1±0.5 vs. 2.1±0.3 mEq/24 h) was significantly lower and PRA (6.0±2.6 vs. 1.9±1.0 ng Ang 1/mL/h) higher in bile duct ligated than in sham-operated rats. No differences were found between UDCA or placebo-treated bile duct ligated rats. CrCl was similar between sham (0.39±0.12 mL/min/100 g BW) and UDCA (0.32±0.16) but significantly lower in placebo-treated (0.28±0.07) than sham-operated rats (p<0.05). Conclusion: UDCA administration had very mild effects on renal function abnormalities induced by experimental obstructive jaundice in rats. However, portal hypertension and biochemical abnormalities were partially improved.
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