SummaryA few considerations are evoked on the role of nitrogen metabolism imbalance in neurological manifestations associated with liver disease, as seen in hepatic coma and hepato-lenticular degeneration.Related to this problem is the study of the possible modes of action of ammoniac compounds which are prone to induce the symptomatology of hepatic coma in some cirrhotic patients.After comprehensive study of actually known facts about hepato-lenticular degeneration, emerges the conclusion that the nervous and hepatic changes are not directly correlated.