Using Pharmacokinetic- Pharmacodynamic Relationships to Predict the Effect of Poor Compliance
作者:
Jean-Pierre Boissel,
Patrice Nony,
期刊:
Clinical Pharmacokinetics
(ADIS Available online 2002)
卷期:
Volume 41,
issue 1
页码: 1-6
ISSN:0312-5963
年代: 2002
出版商: ADIS
关键词: Patient compliance;Pharmacokinetic pharmacodynamic relationships
数据来源: ADIS
摘要:
Since it is difficult to improve patient compliance to drug prescriptions, an alternative is to select a drug with less consequences for poor compliance, that is, a drug that has the capacity of ’forgiveness’. Forgiveness is the property of a drug which, when compared with another medicine with different pharmacokinetics and/or concentration-effect relationships, blunts the consequences of missing one or two doses in a row, or has a greater variability in the timing of intake. Simulations show that drugs with a concentration-effect relationship modelled with an effect compartment, for example a delayed response, have more forgiveness. A marker of forgiveness would be of some help for doctors deciding which drug to prescribe to patients who are poor compliers.
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