T-helper 1 and T-helper 2 paradigm in the acquisition of peripheral graft tolerance
作者:
Xin Zheng,
Xian Li,
Masayuki Noguchi,
Yongsheng Li,
Terry Strom,
期刊:
Current Opinion in Organ Transplantation
(OVID Available online 2000)
卷期:
Volume 5,
issue 1
页码: 42-48
ISSN:1087-2418
年代: 2000
出版商: OVID
数据来源: OVID
摘要:
The acquisition of transplantation tolerance is an active, highly regulated, and multistep process. In this review, we critically examine the validity and limits of the Th1/Th2 paradigm during the period of tolerance induction. We emphasize that host response to major histocompatibility complex–mismatched allografts encompasses an unusually large population of T-cell clones and involves both direct and indirect recognition of foreign major histocompatibility complex antigen. Thus, control of robust expansion of alloaggressive T-cell clones and proliferation is a critical initial step in the acquisition of transplantation tolerance.
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