The effects of climatically deviating periods of at least four years on discharge were investigated employing flow duration curves in the Upper Loire basin, France. The periods were determined using the standardized cumulative yearly deviation from the mean precipitation for ten climate stations. Flow duration curves from 27 catchments were determined and parameterized for each period. Results show that the effect of precipitation on discharge is more pronounced than the effect of temperature. They also show that the parameter values that determine the flow duration curve differ significantly between dry and wet periods. Furthermore the effect of drought on discharge is larger than the effect of wetness. Catchments with a high variability of discharge are more sensitive to changes of precipitation than catchments with a low variability of discharge.