Permeability of Blood Vessels in Experimental Gliomas: Uptake of99mTc‐Glucoheptonate and Alteration in Blood‐Brain Barrier as Determined by Cytochemistry and Electron Microscopy
作者:
Izhak Nir,
Daniel Levanon,
Galina Iosilevsky,
期刊:
Neurosurgery
(OVID Available online 1989)
卷期:
Volume 25,
issue 4
页码: 523-532
ISSN:0148-396X
年代: 1989
出版商: OVID
关键词: Blood‐brain barrier;Chemically induced gliomas;Horseradish peroxidase;Tight junctions
数据来源: OVID
摘要:
&NA;Experimental gliomas were induced in rats by prenatal exposure to ethyl nitrosourea. Changes in the blood‐brain barrier were determined by the uptake of a water‐soluble compound,99mTc‐glucoheptonate. Increased uptake of99mTc‐glucoheptonate was measured in intact tumors and in various sectors of dissected tumors. The extent of99mTc‐glucoheptonate uptake greatly varied among different tumors and among different sectors of the same tumor. Ultrastructural and cytochemical analysis of the capillary endothelial wall revealed major alterations in tight junctions, which became permeable to horseradish peroxidase. In brain tissue around the tumors, uptake of99mTc‐glucoheptonate and ultrastructure of tight junctions were comparable to normal brain capillaries. The results of the present study indicate that altered endothelial tight junctions may provide the main route of transport of99mTc‐glucoheptonate through the endothelial wall. (Neurosurgery25:523‐532, 1989)
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