Population Studies in Northern Sweden 18. Geographical Covariation between Hypercholesterolemia and Finnish Genetic Influence
作者:
P.-O. Nylander,
K. Asplund,
L. Beckman,
B. Stegmayr,
I. Johansson,
期刊:
Human Heredity
(Karger Available online 1993)
卷期:
Volume 43,
issue 3
页码: 147-154
ISSN:0001-5652
年代: 1993
DOI:10.1159/000154170
出版商: S. Karger AG
关键词: Northern Sweden;Genetic epidemiology;Finnish influence;Cardiovascular diseases;Hypercholesterolemia;Body mass index;Obesity;Coffee consumption;‘boiled’ coffee;MONICA project
数据来源: Karger
摘要:
The population of northern Sweden shows a marked ethnic heterogeneity and a unique distribution of disorders with a monogenic or polygenic background, among them cardiovascular diseases. We have studied variations between 23 North Swedish subpopulations (regions) with respect to hypercholesterolemia and its possible determinants including dietary factors, obesity and the degree of Finnish genetic influence. A significant regional heterogeneity was found concerning hypercholesterolemia, obesity and high consumption of ‘boiled’ coffee. Hypercholesterolemia showed significant geographical covariations with Finnish genetic influence and consumption of ‘boiled’ coffee. The results are consistent with the hypothesis that in addition to environmental factors Finnish genetic influence contributes to the development of hypercholesterolemia and thereby to the increased rate of cardiovascular disease found in northern
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