In brief: The first part of this series of articles discussed basic concepts of resistance training; parts 2 and 3 continued with a discussion of physiological responses and adaptations that occur as a result of such training. In this fourth and concluding article, the authors discuss resistance training as exercise prescription and outline the program design process. They point out the importance of making preliminary assessments; defining specific goals and expectations; and evaluating the individual needs, goals, and demands of the participants to help them benefit from the program as much as possible.