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A Direct Approach to the Synthesis of Famciclovir and Penciclovir

 

作者: BernadetteM. Choudary,   GrahamR. Geen,   PeterM. Kincey,   MartinJ. Parratt,   J. Robert,   M. Dales,   GrahamP. Johnson,   Steven O'Donnell,   DavidW. Tudor,   Neil Woods,  

 

期刊: Nucleosides and Nucleotides  （Taylor Available online 1996）
卷期: Volume 15, issue 5  

页码: 981-994

 

ISSN:0732-8311

 

年代: 1996

 

DOI:10.1080/07328319608002029

 

出版商: Taylor & Francis Group

 

数据来源: Taylor

 

摘要:

Reaction of 2-amino-6-chloropurine with triethyl 3-bromopropane-1,1,1-tricarboxylate followed by decarbethoxylation/transesterification of the unpurified product was the key sequence in synthesising both the anti-herpesvirus agent penciclovir and its oral from famciclovir in three isolated steps.

 

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